CARD8 and Stroke: In contrast, another study evaluating the genetic variants NLRP3-Q705K and CARD8-C10X related to the NLRP3 inflammasome, showed that the NLRP3-Q705K minor allele was associated with an increased risk of stroke/transient ischemic attack, but not myocardial infarction (MI)/angina pectoris, while CARD8-C10X was not associated with any type of CV event87.