After RA patients were stratified according to anti-CCP status and adjustment for age and sex, genotype analysis revealed a statistically increased prevalence of the CC genotype of rs2073618 OPG SNP in anti-CCP positive RA patients compared to HC (Table 5) (OR [95% CI] 1.89 [1.18–3.03], p-value: 0.0077, in the dominant model). The gene discussed is TNFRSF11B; the disease is rheumatoid arthritis.