Finally, Dimitroulas et al., in the same concept of reduced NO plasma levels and consequent impaired vascular homeostasis, investigated the effect of Alanine-glyoxylate aminotransferase 2 (AGTX2) gene polymorphisms on the levels Asymmetric (ADMA) and symmetric (SDMA) dimethylarginines in patients with RA, but found no association between serum concentrations of dimethylarginines and genetic variants of the AGXT2 gene4,70,71. This evidence concerns the gene AGXT2 and rheumatoid arthritis.