MTHFR and atherosclerosis: Moreover, recent studies have investigated the potential role of a few single nucleotide polymorphisms (SNPs) in various genes that are associated with CVD in the general population-such as methylenetetrahydrofolate reductase (MTHFR), TNFα, and ZC3HC1, NFKB or other SNPs such as rs964184 on atherosclerosis in RA4.