The receptor activator of NF-κB (RANK) upregulation induced by high glucose activated NF-κB and then increased the transcription of inflammatory cytokines, and OS-associated genes, Nox4 and its obligate partner, P22phox, resulting in the podocyte injury in DN.234 NF-κB is negatively regulated by some proteins. The gene discussed is TNFRSF11A; the disease is liver dysplastic nodule.