ABCA1 and liver dysplastic nodule: ABCA1 is a transporter, which mediates the cellular cholesterol and phospholipid efflux in an ATP-dependent pathway.77 A large-scale transcriptional analysis of ABCA1 in the DN patients revealed a decrease in its expression in the early stage of DN.78 Podocytes with the ABCA1 gene knocked out aggravated the podocyte injury in ob/ob mice by inducing the accumulation of cardiolipin and mitochondrial dysfunction.