However, inducible NOS (iNOS) is evoked by inflammation.179 In a healthy kidney, nNOS is expressed in cortical tubules but not in glomeruli, whereas eNOS is expressed in glomeruli but not in tubules.180 Increased iNOS in injured kidneys was associated with inflammation in CKD animal models.181 Dual CB1 receptor/iNOS antagonist, MRI-1867 decreased renal inflammation, fibrosis, and OS of obesity-related kidney disease.182 However, the studies about NOS in CKD are not well understood currently. This evidence concerns the gene NOS2 and obesity due to melanocortin 4 receptor deficiency.