A selective TGR5 agonist INT-777 induced mitochondrial biogenesis and then increased the FAO in obesity-associated nephropathy and DN.157 A dual FXR/TGR5 agonist INT-767 played a renal protective role in diabetes- and obesity-related kidney diseases by affecting multiple pathways related to the lipid metabolism, such as the upregulation of AMPK, SIRT1, PGC-1a, and Nrf-1.71 This evidence concerns the gene NR1H4 and obesity due to melanocortin 4 receptor deficiency.