CASP3 and atherosclerosis: The uptake of ox-LDL and modified lipoproteins by macrophages aggravate glomerulosclerosis and increase the risk of atherosclerosis.117 Ox-LDL stimulates the activation of caspase-3 and promotes the apoptosis of macrophages in both the CD36 and Toll-like receptors (TLR2)-dependent pathways, leading to plaque necrosis in advanced atherosclerosis.118,119 And atherosclerosis aggravation can elevate the mortality of CKD.