NLRP3 and lupus nephritis: And Pim-1 inhibitor AZD1208 ameliorated proteinuria, glomerulonephritis, renal immune complex deposits, and serum anti-dsDNA antibody levels in mice with lupus nephritis.279 Post transcription modification like miR-10a/b inhibited the formation of the NLRP3 inflammasome by binding to the 3’-untranslated region of NLRP3 mRNA.280 mir-486a-3p and miR-141-3p showed similar suppression effects of NLRP3 and protected kidneys from chronic injury.281,282