SMAD3 and liver dysplastic nodule: PLK1 inhibitor (BI-2536) was predicted to be the top candidate for depressing 15 genes expression related to DN with a connectivity mapping approach and Integrated Network-based Cellular Signatures (LINCS) L1000 data set querying.321 Indeed BI-2536 ameliorated proteinuria and kidney injury of DN mice by dampening NF-κB and Smad3 signaling.