NLRP3 and chronic kidney disease: The proinflammatory and profibrotic effect of NLRP3 inflammasome has been confirmed in multiple animal models of kidney diseases such as UUO, angiotensin II-induced hypertensive kidney injury, DN, glomerulonephritis, and 5/6 nephrectomy.266 Then we summarize the regulation of NLRP3 inflammasome and the following pyroptosis in CKD.