NLRP3 and chronic kidney disease: The expression of inflammasome components in the kidney was reviewed elsewhere.266 NLRP3 inflammasome is the best-characterized inflammasome in CKD.267 NLRP3 inflammasome is assembled by NLRP3, the adaptor protein apoptosis-associated speck-like protein containing a CARD (ASC) and active caspase 1.