NFE2L2 and glomerulosclerosis: The renal protective role of Nrf2 was proved in multiple CKD animal models.188 Nrf2 deletion aggravated renal fibrosis induced by UUO, OS, and glomerulosclerosis of STZ-induced DN, renal damage of lupus nephritis.189–191 Besides regulating antioxidants, inhibiting inflammation is another mechanism of Nrf2 for protecting renal from injury.