APOL1 and glomerulosclerosis: The peroxidation of mitochondrial cardiolipin mediated by ABCA1 promotes podocytes injury in DN.79 The ox-LDL inhibits the phosphorylation of phosphatidylinositol 3-kinase (PI3K) and Akt, leading to the redistribution and loss of nephrin.107 The G1 and G2 renal-risk variants of the apolipoprotein L1 gene (APOL1) have caused glomerulosclerosis in many African Americans.108