The catabolism of phospholipids is mediated by phospholipase including A1, A2, B1, B2, C, and D. The phospholipase A2 receptor (PLA2R) was revealed as an antigenic target in autoimmune adult membranous nephropathy and anti-PLA2R antibody was regarded as a specific biomarker of membranous nephropathy.32 The gene discussed is PLA2R1; the disease is membranous glomerulonephritis.