APOC3 and chronic kidney disease: And hepatic LDL receptor dysfunction is also one of the mechanisms of reduced LDL catabolism.88 Increased scavenger receptors, such as lectin-like-oxidized LDL receptor 1 (LOX1), CD36, scavenger receptor-A1 (SR-A1), and SR-A2 in CKD mediate the increased uptake of ox-LDL, leading to the activation of inflammatory signaling pathways.89,90 Increased ApoC-III levels and reduced ApoC-II to ApoC-III ratio block the activity of LPL and hepatic triglyceride lipase that mediate the conversion of VLDL to intermediate-density lipoprotein (IDL) and IDL to LDL, respectively.