The forkhead box superfamily is a class of transcription factors with a specific “winged helix structure” DNA binding domain, including several families such as FOXA, FOXC, FOXM, FOXO, and FOXP.185 FOXM1 (forkhead box protein M1) is one of the key genes controlling cell proliferation and its abnormal activation is closely related to the proliferation and division of cancer cells. The gene discussed is FOXM1; the disease is cancer.