Chronic myelogenous leukemia(CML) is most often caused by the lack of autoinhibition of the c-ABL kinase domain in the oncogenic fusion protein BCR-ABL.142 When the ABL gene is translocated from chromosome 9 to the BCR gene on chromosome 22, BCR-ABL is generated. The gene discussed is ABL1; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.