The promising degrader 26 (Fig. 7) and degrader 27 (Fig. 7) induced degradation of EGFR in HCC-827(EGFRe19d) cells with the DC50 values of 45.2 nM and 34.8 nM, respectively.54 It was found that the apoptosis and the G1 phase arrestation of HCC-827 cells were significantly induced by the two degraders. This evidence concerns the gene EGFR and hepatocellular carcinoma.