In 2021, Bian group reported a selective degrader 175 (B03, Fig. 46) for CDK9 by conjugating a selective CDK9 inhibitor BAY-1143572 and pomalidomide.316 The degrader 175 (B03) induced the degradation of CDK9 in acute myeloid leukemia cells with DC50 of 7.6 nM, which was superior to the reported CDK9 degraders. The gene discussed is CDK9; the disease is acute myeloid leukemia.