The degrader 24 had good antiproliferative activity against a variety of EGFR mutant cells, such as PC9(EGFRDel19) cells, HCC-827(EGFRDel19) cells, and H1957(EGFRL858R/T790M) cells, with IC50 of 413 nM, 1.34 μM, and 657 nM, respectively. The gene discussed is EGFR; the disease is hepatocellular carcinoma.