At the same time, James group reported that degrader 152 (UNC6852, Fig. 37) also reduced the protein level of EED (DC50 = 0.79 μM) and EZH2 (DC50 = 0.3 μM) on HeLa cells.262 In summary, these data demonstrated that the degradation of the subunit of the PRC2 complex could cause the complex to lose its function, which was expected to be a method for PRC2-mediated cancer treatment. The gene discussed is EZH2; the disease is cancer.