The human genome encodes four YEATS domain-containing proteins, namely ENL, AF9, YEATS2, and GAS41.230 Among them, ENL protein is essential for the development of acute myeloid leukemia(AML).231 When ENL is knocked out, it would induce anti-leukemia effect and inhibit the growth of leukemia in vivo and in vitro. Here, YEATS4 is linked to leukemia.