PARK8 is one of the genes associated with Parkinson's disease (PD), which encodes leucine-rich repeat kinase 2 (LRRK2).462 To date, a large number of disease-associated LRRK2 mutations have been identified and five mutations (R1441C, R1441G, Y1699C, G2019S, and I2020T) are associated with PD pathogenesis. This evidence concerns the gene LRRK2 and Parkinson disease.