eIF4E (Eukaryotic translation initiation factor 4E) is a cap-binding protein that can specifically recognize the cap structure at the 5’-end of mRNA.58 It plays an important role in the initiation of eukaryotic translation.59 Studies have found that the overexpression of eIF4E is related to cancer and other diseases, and eIF4E levels are elevated in 30% of cancers, so eIF4E has become an attractive target for drug discovery.60 Here, EIF4E is linked to cancer.