VHL and acute lymphoblastic leukemia: In 2019, Zhou and Zheng group reported the first selective Bcl-xl degrader 74 (DT2216, Fig. 20) by coupling the toxicity ABT-263 with the VHL ligand to achieve efficient Bcl-xl degradation.134 The DC50 and Dmax were 63 nM and 90.8% in MOLT-4 T-cell acute lymphoblastic leukemia(T-ALL) cells.