Phosphorylation of Rb leads to the release of the transcription factor E2F to activate many transcription genes that are responsible for cell cycle progression.298 Among CDKs, CDK4/6 play an important role in the cell cycle and are often overexpressed or overactivated in tumor samples.299 However, the current clinical use of CDK4/6 inhibitors have limited its application due to its drug resistance and off-target effects.300 So far, many selective and nonselective degraders of CDK4/6 have been reported.301–306 Here, we make a supplement to the CDK4/6 degraders reported in recent 2 years. The gene discussed is CDK4; the disease is neoplasm.