AR and Familial prostate cancer: Primarily, they utilized TD-106 as an E3 ligase ligand, a novel CRBN ligand identified in their previous studies.22 Among all the AR degraders, the representative degrader 7 (TD-802, Fig. 4) could effectively induce the degradation of AR protein with DC50 of 12.5 nM and the Dmax of 93% in LNCaP prostate cancer cells.23 In addition, the degrader 7 (TD-802) showed good liver microsomal stability and pharmacokinetic properties in vivo.