MDM2 and leukemia: In 2021, Tang group reported a series of MDM2 ligands which were designed and synthesized based on the four-component Ugi reaction, and then synthesized MDM2 degraders based on these ligands.164 After extensive optimization based on antiproliferative activity and MDM2-degradation activity, the degrader 98 (WB214, Fig. 23) was determined to be the degrader with the best MDM2-degradation activity in leukemia cells.