EGFR and hepatocellular carcinoma: In HCC-827 (EGFRe19d) cells and H3255 (EGFRL858R) cells, both the degrader 22 (MS39) and degrader 23 (MS154) could efficiently induce the degradation of mutant EGFR proteins, with DC50 of 5.0 nM, 3.3 nM, and 11 nM, 25 nM, respectively.