SMARCA4 and acute myeloid leukemia: The studies have found that two ATPases in the complex SMARCA2/4 are potential cancer treatment targets.421 SMARCA4 plays a tumor suppressor effect in solid tumors, but in AML it is necessary to maintain the oncogenic transcription program and drive proliferation.422 It has been reported that the double allosteric inhibitor of SMARCA2/4 ATP enzyme activity effectively inhibited the proliferation of the SMARCA4 mutant xenograft model.423