MAPT and Alzheimer disease: In 2021, Wang group developed a novel tau protein degrader 240 (C004019, Fig. 80) by recruiting VHL E3 ligase.469 It showed selective and potent tau protein degradation both in vitro cellular models (HEK293 and SH-5Y5Y) and in vivo mice models (hTau-transgenic and 3xTg-AD).