In addition, hypofunction of NMDARs has been reported in schizophrenia due to alterations in signaling pathways through NMDAR-interacting proteins such as neuregulin-ErbB4 receptors [42, 43, 77], disrupted-in-schizophrenia 1 (DISC1) [44, 78], calcineurin [79], and α7 nicotinic acetylcholine receptors [45, 80]. The gene discussed is DISC1; the disease is schizophrenia.