Eimeria infections are commonly seen in a variety of mammalian hosts. This genus of unicellular sporozoan parasites causes significant disease (coccidiosis) in different livestock species leading to economic losses for agricultural producers. Especially the production of cattle, sheep, and goat is strongly dependent on efficient coccidiosis control. However, many other livestock hosts like, e.g., camelids, bison, rabbits, and guinea pigs may benefit from reduced parasite transmission and targeted control measures as well. Besides livestock, also wildlife and pet animals may be affected by Eimeria infections resulting in clinical or subclinical coccidiosis. Wildlife herd health is crucial to conservation efforts, and Eimeria species are a prevalent pathogen in multiple mammalian wildlife species. This review aims to highlight the epidemiology of mammalian Eimeria infections in both wild and domestic ruminants, including host specificity, transmission, survival of environmental oocysts, occurrence, and risk factors for infection. Understanding general drivers of Eimeria infection may support adequate livestock and wildlife management. Furthermore, control options for livestock with reference to management factors, drug application, and alternative approaches are discussed. The goal of Eimeria control should be to reduce pathogen transmission in different host species and to improve sustainable livestock production. Controlling Eimeria infections in livestock is important considering both their animal welfare impact and their high economic relevance.