According to the images of immunohistochemically stained sections, ZQFZ increased the number of CD4+ and CD8+ T cells (Figure 5A, 5B, 5E, 5F), and IFN-γ levels in both colorectal tumors and the spleen (Figure 5D, 5H), but had no effect on IL-4 levels (Figure 5C, 5G). Here, IL4 is linked to colorectal neoplasm.