We initially examined the expression of ALG family members (ALG1, ALG2, ALG3, ALG5, ALG6, ALG8, ALG9, ALG10, ALG11, ALG12, ALG13, ALG14) in CRC and normal tissues through the online analytic tool (TNMplot: https://tnmplot.com/analysis/), and found that all ALG members were upregulated in CRC tissues, except for ALG9 and ALG13 (Figure 1A–1L). The gene discussed is ALG8; the disease is colorectal carcinoma.