Notably, the analysis of the microarray data from the two HCC subject cohorts deposited at GEO database (n=214 for GSE14520 and n=91 for GSE102079) revealed that the MAP4K4 gene expression was significantly higher in HCC tumors compared with adjacent non-tumor liver tissues (P < 0.0001). Here, MAP4K4 is linked to hepatocellular carcinoma.