FAM53A and osteoarthritis: We found such an eQTL effect below nominal significance levels for five genes in low-grade osteoarthritis cartilage (ALDH1A2, CHMP1A, FAM53A, RPP25, and TGFA), two genes in high-grade osteoarthritis cartilage (FAM53A and LTBP1), and one gene in synovium (CRADD) (Figure 7C).