Two high-confidence effector genes were shown to be differentially expressed in high-grade compared to low-grade osteoarthritis cartilage (in high-grade osteoarthritis cartilage, ALDH1A2 is overexpressed with FDR = 0.0017 and logFC = 0.38 and CRADD is underexpressed with FDR = 0.00067 and logFC = −0.24), thus providing additional supportive evidence for a role in osteoarthritis. Here, ALDH1A2 is linked to osteoarthritis.