A gene set rather similar to those found in the present study (ADCY3, ATP2A1, BCDIN3D, BDNF, CADM2, ETV5, FTO, GNPDA2, GPRC5B, HNF4G, LINGO2, LMX1B, MC4R, MTCH2, NEGR1, POC5, PTBP2, RASA2, SEC16B, TFAP2B, TLR4, TMEM18, ZC3H4, ZFP64) was underlying the causal association between BMI and PCOS in a previous MR study as well [25]. The gene discussed is ZC3H4; the disease is polycystic ovary syndrome.