A gene set rather similar to those found in the present study (ADCY3, ATP2A1, BCDIN3D, BDNF, CADM2, ETV5, FTO, GNPDA2, GPRC5B, HNF4G, LINGO2, LMX1B, MC4R, MTCH2, NEGR1, POC5, PTBP2, RASA2, SEC16B, TFAP2B, TLR4, TMEM18, ZC3H4, ZFP64) was underlying the causal association between BMI and PCOS in a previous MR study as well [25]. The gene discussed is GPRC5B; the disease is polycystic ovary syndrome.