A gene set rather similar to those found in the present study (ADCY3, ATP2A1, BCDIN3D, BDNF, CADM2, ETV5, FTO, GNPDA2, GPRC5B, HNF4G, LINGO2, LMX1B, MC4R, MTCH2, NEGR1, POC5, PTBP2, RASA2, SEC16B, TFAP2B, TLR4, TMEM18, ZC3H4, ZFP64) was underlying the causal association between BMI and PCOS in a previous MR study as well [25]. Here, MC4R is linked to polycystic ovary syndrome.