CPA1 and Zika virus infectious disease: Both CpA-Dcr2 and CpA-R2d2 transgenic mosquito midguts displayed significantly lower ZIKV infection intensities than did WT control mosquitoes, with a 4.2- and 1.8-fold reduction in median viral titers for CpA-Dcr2 and CpA-R2d2, respectively at 7 dpi (Fig 2D, Mann–Whitney test, ***P < 0.001, ****P < 0.0001).