HspB1 harbored by far most of the mutations as compared to HspB3 and HspB8: In a systematic study of a cohort of 510 unrelated index patients with peripheral neuropathies, 32 patients were found to have mutations in sHSPs (32/510; 6.3%) (Echaniz-Laguna et al. 2017). The gene discussed is HSPB8; the disease is peripheral neuropathy.