GPNMB and breast carcinoma: In addition, the HPA database demonstrated [21] that AP2B1, APP, GPNMB and DLST were highly expressed in breast cancer (Figure 5D); the increased expression of AP2B1 (cut-off value, 75%) was significantly associated with the survival rate (p = 0.044) of 1075 patients with breast cancer (Figure 5E).