The top ten paths listed by ascending P-value are, as shown in Figure 5A: (1) linoleic acid metabolism, (2) retinol metabolism, (3) steroid biosynthesis, (4) chemical carcinogenesis, (5) complement and coagulation cascades, (6) circadian rhythm, (7) prion diseases, (8) PPAR signaling pathway, (9) wnt signaling pathway, and (10) arachidonic acid metabolism. This evidence concerns the gene PPARA and prion disease.