CREB1 and diabetic kidney disease: This was indeed demonstrated by the following evidence: (1) We confirmed the interaction between puerarin and Gnai1 by DARTS assay followed by Western blot; (2) Gnai1 expression is increased in the glomeruli of human DKD; (3) Puerarin increases cAMP production which was suppressed by overexpression of Gnai1 in podocytes; (4) Puerarin also induces CREB phosphorylation and overexpression of CREB reduces podocyte apoptosis which mimic the effects of puerarin; and (5) Inhibition of cAMP/PKA pathway attenuates the protective effects of puerarin on high glucose‐induced podocyte apoptosis.