Wang et al. elaborated in their study that DNMT1 recruited by KCNQ1OT1 induced the methylation of RUNX3, which led to the downregulation of RUNX3 expression, thereby promoting cardiac microvascular endothelial cell injury as well as inflammatory reaction in acute myocardial infarction.26 Here, KCNQ1OT1 is linked to acute myocardial infarction.