Regulated transcription of gene involved in apoptosis, cytoskeleton, adhesion/extracellular matrix, proliferation, stress response, migration, angiogenesis, and signal transduction.Regulation of genes and proteins involved in cancer cell proliferation and metastasis, such as IL6, IL8, IL15, OPN, VEGFA, VEGFD, FGF17, MMP2, MMP3, TIMP1, PRKAA, and PRKACAAntiproliferative effects. This evidence concerns the gene SPP1 and cancer.