In addition, previously we also found that nitric oxide prevents overexpression of EMMPRIN in a murine model of AMI9 and during carotid atherosclerosis, and therefore MVO after endothelial dysfunction, which is related to a depletion of NO availability, may be prevented after inhibition of EMMPRIN.28 However, further studies must be performed to explore role of NAP9 in these contexts. The gene discussed is BSG; the disease is carotid atherosclerosis.