CAT and neoplasm: Second near‐infrared light‐activated Cu‐doped polypyrrole nanozyme (CuP) with hyperthermia‐enhanced trienzyme‐like activities, including CAT, POD, and GPx, are elaborately synthesized via a straightforward one‐step procedure for causing irreversible oxidative stress damage to tumor cells and reversing immunosuppressive tumor microenvironment by re‐educating macrophage from pro‐tumoral M2 to anti‐tumoral M1 phenotype.