NNMT protein assessed by IHC staining was significantly more highly expressed in primary ccRCC than in non‐tumour tissue of cohort 1, in unpaired (Figure 1A, n = 64, fold‐changes [fc] = 3.58, p = 1.32 × 10–16) as well as in paired samples (Figure 1A, n = 44, fc = 3.96, p = 3.41 × 10–13). This evidence concerns the gene NNMT and nonpapillary renal cell carcinoma.