On the contrary, there are weight loss studies in which interventions have great impact on cardiovascular risk markers.31 For example, bariatric surgery in people with severe obesity is associated with decreased overall mortality32 and prevention of type 2 diabetes.33 Today, it is not uncommon that people with type 1 diabetes are overweight and due to that insulin-resistant.18 This may guide preventive measures by improving risk assessment in which weight is one important risk factor.34 Here, INS is linked to obesity due to melanocortin 4 receptor deficiency.