The median PCT and CRP levels in 115 patients with bacterial co-infection [2.09 ng/ml (range 0.99–3.6 ng/ml) and 43.2 mg/l (range 20.5–75.3 mg/l)] were higher than those in 258 patients with non-bacterial co-infections [0.99 ng/ml (range 0.63–2.00 ng/ml) and 26.4 mg/l (range 14.2–46.3 mg/l), respectively, both p < 0.001] (Table 4). This evidence concerns the gene CRP and coinfection.