REN and Sepsis: Given its vasopressor activity which allows the restoration of vascular tone and arterial pressure through both venous and arterial constriction, (27) the interest of angiotensin II administration has been studied in vasodilatory shock and especially in septic shock, since a relative renin-angiotensin system failure has been evidenced in sepsis, illustrated by a relative decrease in angiotensin II plasma levels combined with a decrease in sensitivity to angiotensin II stimulation (26).