STAT3 and colitis: Moreover, Wnt pathway and inflammatory signaling pathways, such as nuclear factor-kappa B (NF-κB), Janus kinase-signal transducer and activator of transcription 3 (JAK-STAT3), and mitogen-activated protein kinase (MAPK), affect each other, which regulate inflammatory factors' secretion during the pathogenesis of colitis (18, 63).