After 24 h of incubation with the LOPAC compounds, we initially used FITC-conjugated dextran to measure the dextran uptake by MDMi cultures generated from a young healthy individual homozygous for the CD33 AD risk allele (rs3865444CC), which is known to have reduced uptake ability compared to the CD33 AD protective allele (rs3865444AA) (Bradshaw et al., 2013). The gene discussed is CD33; the disease is Alzheimer disease.