Our findings, together with the evidence showing that the CB1R positive allosteric modulator GAT211 failed to induce any changes in GAERS and NEC anxiety-like behaviors and motor activity in other anxiety tests (Roebuck, 2021), suggest that the control of anxiety/motor response by the eCBs in GAERS and NEC is strain-dependent and evident when phasically activated. This evidence concerns the gene CNR1 and Anxiety.