HES1 and myocardial infarction: Li et al. studied a MI model and found that deer antler activated the Notch signaling pathway in EPC, upregulated the protein expression of Jagged 1, Notch1, NICD and HES1 and the mRNA expression of Hes1 and Hey2; it also promoted the mobilization of EPCs, endothelial repair and angiogenesis after MI (88).