Therefore, the early diagnosis of SMD is challenging for clinicians, and there is no clinical “gold standard.” At present, the commonly used indicators of septic cardiac dysfunction include BNP, NT-proBNP, and echocardiographic indicators, such as LVEF, E/E′, etc. The gene discussed is NPPB; the disease is spondyloepimetaphyseal dysplasia, Strudwick type.