NOX4 and heart failure: Antioxidant puerarin could inhibit ferroptosis via increasing GPX4 and ferritin heavy chain 1 (FTH1), and down-regulating expression of NOX4, which could improve cell viability in rats, reduce death of H9C2 cardiomyocytes treated with erastin or isoproterenol (ISO) and retard the development of heart failure (64).