Protein kinase C (PKC) isozymes are a group of serine/threonine kinases whose activity and levels are dispensed in several pathological heart conditions, including atherosclerosis (AS), myocardial infarction (MI), acute ischaemic, cardiac hypertrophy, cardiac arrhythmia, HF, and cardiac fibrosis (86, 87). The gene discussed is PRRT2; the disease is cardiac arrhythmia.