Empagliflozin-associated renoprotection in injured proximal tubules of mice with apolipoprotein E (APOE) deficiency given a high-fat diet is mediated by increased ketone body, which corrects mechanistic target of rapamycin complex 1 (mTORC1) hyperactivation detected in non-proteinuric and proteinuric diabetic kidney disease (52). This evidence concerns the gene APOE and hyperinsulinemic hypoglycemia, familial, 4.