The IL-8 gene was upregulated at 6, 12, and 24 hours and downregulated at 50 hours after infection in the planktonic group; in the biofilm group, the IL-8 was upregulated at 12 and 24 hours after infection and downregulated at 6 and 48 hours after infection (Figure 6C). The gene discussed is CXCL8; the disease is infection.