Global analysis of lung tissues and BALF of infected mice with MA-ARDS revealed elevated levels of the cytokines and chemokines also reported in the serum of severe malaria in humans mainly, IL-1, IL-6, IL-8, IL-10, TNF-α, IFN-γ, MCP-1/CCL2, MIP-2/CXCL2, IP-10/CXCL10, KC/CXCL1, VEGF, PIGF (Day et al., 1999; Lovegrove et al., 2008; Epiphanio et al., 2010; Van den Steen et al., 2010; Taylor et al., 2012; Deroost et al., 2013; Pham et al., 2017; Galvao-Filho et al., 2019). This evidence concerns the gene CXCL2 and malaria.