demonstrated that IFN-γ produced by CD8+T cells was required for inducing the differentiation of TNF-a/iNOS-producing monocyte-derived dendritic cells in the lung, and for the development of MA-ARDS in PbNK65-infected C57BL/6 mice (Galvao-Filho et al., 2019). This evidence concerns the gene TNF and acute respiratory distress syndrome.