Researchers found that NLRP3-related inflammation was activated in the fat pads of leptin-deficient mice and high-fat diet-fed obese mice and that NLRP3-dependent caspase-1 activation in hypertrophic adipocytes may induce obesity and adipocyte death through pyroptosis [91]. Here, CASP1 is linked to obesity due to melanocortin 4 receptor deficiency.