Researchers found that NLRP3-related inflammation was activated in the fat pads of leptin-deficient mice and high-fat diet-fed obese mice and that NLRP3-dependent caspase-1 activation in hypertrophic adipocytes may induce obesity and adipocyte death through pyroptosis [91]. The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.