KEAP1 mutations were reported to be enriched in patients with high TMB lacking T-cell infiltration and immunologically cold (Marinelli et al., 2020), which have been associated with decreased efficacy of ICIs in NSCLC in published studies (Papillon-Cavanagh et al., 2020; Di Federico et al., 2021). The gene discussed is KEAP1; the disease is non-small cell lung carcinoma.