Consistent with activation of ILC2, qRT-PCR analysis of gp130F/F antra showed increased expression of ILC2 markers Gata3, Areg, Il9 and Il4 (Figure 5F; Figure 3E), but importantly not all were induced in an IL-33 dependent manner, with Gata3 and Areg increased similarly in antra and tumours of gp130F/F and gp130F/FIl33−/− mice. The gene discussed is GATA3; the disease is neoplasm.