Fibrosis levels by Fibroscan measurement declined significantly over time from baseline to the end of five year follow-up in patients treated with Peg-IFN/ADV (−0.76 kPa, P = 0.023) and Peg-IFN/TDF (−0.43 kPa, P = 0.030) but not in the untreated patients (−0.32 kPa, P = 0.399), Supplementary Figure 5. Here, IFNA1 is linked to fibrosis.