For example, RyR1 mutations have been primarily linked to malignant hyperthermia (MH) (FuJII et al., 1991; Gillard et al., 1991), central core disease (CCD) (Zhang et al., 1993), multi-minicore disease (MmD), congenital fiber type disproportion (CFTD), and centronuclear myopathy (CMD) (Treves et al., 2008; Amburgey et al., 2011; Amburgey et al., 2013; Snoeck et al., 2015; Jungbluth et al., 2018), and account for more than 30% of total congenital myopathy cases (Zvaritch et al., 2009; Zhou et al., 2013). This evidence concerns the gene RYR1 and multiminicore myopathy.