RYR2 and heart failure: RyR2 mutations have been associated with several cardiac conditions such as catecholaminergic polymorphic ventricular tachycardia (CPVT) (Laitinen et al., 2001; Itoh et al., 2021), sudden cardiac death (Blayney and Lai, 2009; Aiba et al., 2016), heart failure (HF) (Ran et al., 2010), and other cardiac arrhythmias (Priori et al., 2001).