RYR1 and catecholaminergic polymorphic ventricular tachycardia: showed a CPVT mutation, A165D, located at the same inter-subunit interface of NTD can also perturb the conformation of the closed-state tetramer structure of NTD, suggesting that a similar disease mechanism of NTD mutations applies to both RyR1 and RyR2 given the strong conservation of NTD between them.