Francesca et al. conducted a series of experiments to determine whether SIRT1 can protect against DNA damage-induced cell senescence and phenotype transformation of VSMCs in diabetes, they found that loss of SIRT1 in diabetes can accelerate DNA damage, which further exacerbated VC, while SIRT1 activation reduced DNA damage partially by deacetylating around H3K27ac mark within the transcription start site, which further promoted the formation of the active MRN repair complex (MRE11 RAD50, NBS1) (Bartoli-Leonard et al., 2021). The gene discussed is SIRT1; the disease is diabetes mellitus.