The normal expression of SIRT1 is very important for maintaining physiological function, and many diseases are associated with dysregulated SIRT1 expression, such as cancer, neuroinflammation-related diseases, depression, and cardiovascular diseases (Karbasforooshan and Karimi, 2017; Lu et al., 2018; Alves-Fernandes and Jasiulionis, 2019; Jiao and Gong, 2020). This evidence concerns the gene SIRT1 and major depressive disorder.