In CKD, SIRT6 can inhibit the osteogenic transdifferentiation of VSMCs from a contractile phenotype to a synthetic phenotype, which is the central process in medial calcification, by binding to runt-related transcription factor 2 (Runx2) and causing its deacetylation (Li et al., 2022b). This evidence concerns the gene RUNX2 and chronic kidney disease.