MAPK3 and hydrops fetalis: In this study, network pharmacological analysis results predicted that the important BP of SGR participated in the treatment of HF included regulation of DNA and RNA transcription, cell proliferation, oxidation-reduction process, apoptotic process, ERK1, and ERK2 cascade, and MAPK cascade, etc. Oxidative stress results in DNA damage and worsens mitochondrial function, leading to organ dysfunction and even aggravating the development of heart failure (Wang C. et al., 2020).