Molecular docking further indicated these 5 identified compounds may exert anti-HF effect by targeting SRC, JUN, TNFα, PPARα, and Sirt1, respectively, but the study on the relationship between identified compounds and their targeted protein is still lacking; thus, we draw a hypothesis that Istidina may be possible anti-HF agent by targeting SRC, which required our further verification in future. This evidence concerns the gene PPARA and hydrops fetalis.