In mice transplanted with intestinal flora from BD patients, elevated levels of inflammatory cytokines and TRANK1 messenger RNA (TRANK1 is an important risk gene of BD) in the hippocampus and prefrontal cortex may be associated with LPS stimulation of BV-2 microglia (Lai J. et al., 2021). This evidence concerns the gene TRANK1 and Behcet disease.