Furthermore, LA activated miR-142-3p to enhance the expression of Ras homolog enriched in the brain (Rheb) and subsequently activated mTOR signaling to inhibit proliferation, attenuate melanin production, and induce apoptosis in A375 and B16 melanoma cells (Barry and Parsons, 2016; Zhang et al., 2020). This evidence concerns the gene RHEB and melanoma.