LA downregulated uPA expression in hepatocellular carcinoma by suppressing MKK4/JNK and NF-κB signaling and inhibited invasion and migration of HA22T/VGH and SK-Hep-1 cells (hepatocellular carcinoma cell models) at 5–20 μM (Tsai et al., 2014; Wu M. H. et al., 2018). Here, MAP2K4 is linked to hepatocellular carcinoma.