On one hand, we should consider that ELT anti-inflammatory properties, the modulation of cytotoxic response and restoration of iron overload could be helpful in the attenuation of GvHD; on the other, robust evidence underlines the importance of TGF-β signaling in the dynamics of GvHD (Carli et al., 2012). The gene discussed is TGFB1; the disease is graft versus host disease.