UBE2C and cancer: The UBE2C (Ubiquitin Conjugating Enzyme E2 C) is a conjugating enzyme, that plays a crucial role in cancer progression and its upregulation has been found in various cancers, a recent study demonstrated that overexpression of UBE2C was associated with TMB, microsatellite instability, immune cell infiltration, and diverse drug sensitivities (Jiang et al., 2021).