TP53 and cancer: Furthermore, we examined the shared dysregulated pathways of DEGs by KEGG pathway enrichment analysis and found that the shared up-regulated genes among 28 tumors are functionally associated with pathways that are related to oncogenesis and cell cycle (Figure 2D), such as cell cycle, cellular senescence, p53 signaling pathway, human T-cell leukemia virus 1 infection, microRNAs in cancer, transcriptional dysregulation in cancer (Liu et al., 2020; Hirons et al., 2021; Lee and Dutta, 2009).