To further evaluate whether myricetin induces ER stress in HCC cells, the expression levels of several molecular indicators of ER stress, including BiP, eIF2α, p-eIF2α, IRE1α, and CHOP, were checked by western blotting after SMMC-7721 and Hep3B cells were treated with various concentrations of myricetin for 24 h. This evidence concerns the gene DDIT3 and hepatocellular carcinoma.