In this study, we report that myricetin induced ER stress in HCC cells, as indicated by typical cellular morphology (Figure 2(a)), the release of intracellular calcium and the activation of ER stress and UPR signaling molecules, including BiP, eIF2α, IRE1α, and CHOP (Figure 2(b)). Here, ERN1 is linked to hepatocellular carcinoma.