Furthermore, Shaker et al. demonstrated celastrol can ameliorate inflammatory symptoms in mice colitis model, and the relevant mechanism involved the inhibition of the NOD-like receptor protein 3 inflammasome (NLRP3-inflammasome), reduction of the levels of IL- 23 and IL-17A as well as the up-regulated expression of IL-10 and TNF-α (Shaker et al., 2014). The gene discussed is TNF; the disease is colitis.