SREBF1 and fatty liver disease: Herein, we found that administrated AgNPs significantly induced worsened hepatic steatosis and increased liver injury in mice due to the hyperactivation of SREBP-1c-mediated de novo lipogenesis (DNL), proinflammatory activation of cytokines, and elevated induction of oxidative stress and global DNA methylation, indicating the potential exacerbation of NAFLD and development NASH.