SREBP-1c is a master transcript factor regulating expressions of DNL rate-limiting enzymes, including Fasn, Acc1, and Scd1, which controlled the rate of DNL and are implicated in hepatic steatosis and NAFLD pathogenesis (Chen et al., 2018; Zhou et al., 2021). This evidence concerns the gene ACACA and metabolic dysfunction-associated steatotic liver disease.