ERH is reported to interact with some other proteins (48), such as mediator complex subunit 31/comparative gene identification protein 125 (MED31/CGI-125), tumor protein p53 (TP53), 70 kDa heat shock protein 8 (heat shock protein, HSPA8) in Li-Fraumeni syndrome, but these results have not been confirmed in experiments. The gene discussed is MED31; the disease is Li-Fraumeni syndrome.