Because most non-mediastinal diffuse large B-cell lymphomas (DLBCL) and mediastinal large B-cell lymphomas do not express galectin-1 and c-Jun, the combination of galectin-1 and c-Jun can be used as a diagnostic biomarker to distinguish other lymphomas with the same morphological or molecular characteristics as cHL and ALCL. Here, LGALS1 is linked to lymphoma.