CBL0137 exerts its anti-cancer effect through intercalating into DNA and inducing genome-wide nucleosome destabilization that activates a cascade of anti-cancer effects, including trapping the histone chaperone Facilitates Chromatin Transcription (FACT) on chromatin, inhibition of DNA damage repair, p53 activation, NFκB suppression, and induction of TRAIN (Transcription of Repeats Activates Interferon) (5–7). This evidence concerns the gene TP53 and cancer.