However, the CBL0137/panobinostat combination did not induce significant changes in the levels of acetylation or methylation of specific histones associated with KMT2A-r leukemia or in the expression levels of leukemogenic KMT2A target genes such as HOXA9 and MEIS1 before induction of apoptosis. The gene discussed is HOXA9; the disease is leukemia.