RRM2 and hepatocellular carcinoma: Compared with normal tissue, the PYCR1, LPCAT1, and G6PD significantly expressed more in HCC tissue, while CYP3A5, CYP2C9, BDH1, ADH4, and ADH1C expressed less (Figure 8A), and the expression of RRM2, PTGES, and HK2 has no significant difference between two tissues (Figure S4A).